Research progress on the effects of mitophagy on oocyte development in women with diminished ovarian reserve

VernacularTitle:线粒体自噬影响卵巢储备功能减退女性卵母细胞发育的研究进展
Author: Yaxuan SUN ¹ ; Ruihong MA ¹ ; Saihua MA ¹ ; Linling WU ¹ ; Yu WU ¹
Author Information

1. 天津中医药大学第一附属医院　国家中医针灸临床医学研究中心，天津　300381
Publication Type:Journal Article
Keywords: Mitophagy; Diminished ovarian reserve; Oocyte
From: Chinese Journal of Reproduction and Contraception 2024;44(11):1200-1204
CountryChina
Language:Chinese
Abstract: Diminished ovarian reserve (DOR) is a common reproductive endocrine disease in women, which is an important factor leading to the decline of female fertility. The number and quality of oocytes in DOR women gradually decrease with age, which leads to the decline of fertility in women. Mitochondrial dysfunction is an important cause of oocyte quality decline. In recent years, studies have found that mitophagy, as an important mechanism of self-repair and metabolic balance in cells, is closely related to oocyte development. This article focuses on the regulation of mitochondrial DNA copy number and mutation, ATP content, mitochondrial reactive oxygen species content, mitochondrial membrane potential changes on mitophagy, and the effects on oocyte development and the regulation of drugs on oocyte mitophagy.