Research progress of autophagy in female reproductive disorders
10.3760/cma.j.cn101441-20240702-00235
- VernacularTitle:自噬在女性生殖障碍性疾病中的研究进展
- Author:
Shenglan FU
1
;
Wenan LI
1
;
Zhijin HOU
1
;
Yushi MENG
1
Author Information
1. 昆明医科大学第二附属医院生殖医学科，昆明 650101
- Publication Type:Journal Article
- Keywords:
Autophagy;
Endometriosis;
Polycystic ovary syndrome;
Beclin-1 protein;
Microtubule-associated protein 1 light chain 3;
Chronic endometritis;
Recurrent abort
- From:
Chinese Journal of Reproduction and Contraception
2025;45(1):85-89
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, more and more studies have shown that autophagy is closely related to female reproductive process. Autophagy is a widespread and highly conserved degradation system in eukaryotes that can be activated under conditions such as hypoxia, starvation, lack of nutrients, or extreme pH. In terms of reproductive health, autophagy can improve reproductive dysfunction by removing damaged organelles and regulating cell growth and metabolism. Appropriate regulation of autophagy helps to improve oocyte quality, delay ovarian aging, fine-regulate endometrial growth, and ensure successful implantation of embryos. However, the abnormality of autophagy pathway may cause problems such as activation of pelvic inflammatory cytokines, reduced endometrial receptivity, abnormal follicle development, and weakened invasion ability of trophoblast cells, thus leading to the occurrence and development of reproductive disorders such as endometriosis, chronic endometritis, polycystic ovary syndrome, early-onset ovarian insufficiency, and recurrent spontaneous abortion. This article reviews the mechanism and therapeutic targets of autophagy in female reproductive diseases, providing clinical ideas and diagnosis and treatment strategies for improving female reproductive health.
