Modification strategies for improving anti-enzymatic stability of antimicrobial peptides
10.3867/j.issn.1000-3002.2025.01.007
- VernacularTitle:提高抗菌肽抗酶解稳定性的结构修饰策略研究进展
- Author:
Shuyuan JIANG
1
;
Changhao ZHANG
;
Taoran WANG
Author Information
1. 延边大学药学院,吉林 延吉 133002;军事医学研究院国家安全特需药品全国重点实验室,北京 100850
- Publication Type:Journal Article
- Keywords:
antimicrobial peptides;
enzymatic stability;
structural optimization strategy
- From:
Chinese Journal of Pharmacology and Toxicology
2025;39(1):69-78
- CountryChina
- Language:Chinese
-
Abstract:
As antibiotic resistance becomes increasingly concerning,antimicrobial peptides,as a new type of antibiotic alternative,have attracted more attention.However,the low enzymatic stability of antimicrobial peptides severely limits their clinical applications.To address this issue,researchers have developed various structural modification strategies,including the introduction of unnatural amino acids,peptide chain cyclization and chemical group modification.This article reviews the basic principles and cases of the above modification strategies analyzes the advantages and disadvantages of different modification strategies and recommends ways these strategies can be optimized.In addition,this article predicts the developments of and potential challenges to strategies for enhancing enzymatic stability of antimicrobial peptides in the hope of providing references for subsequent research and development of antimicrobial peptides.
