Research progress in in vivo analytical methods and the metabolism and transport of peptide nanomedicines
10.3867/j.issn.1000-3002.2025.01.001
- VernacularTitle:多肽纳米药物体内分析方法及代谢转运研究进展
- Author:
Chen LI
1
;
Bilige HASEN
1
;
Yun WANG
1
Author Information
1. 北京大学公共卫生学院劳动卫生与环境卫生学系,北京 100191
- Publication Type:Journal Article
- Keywords:
peptide nanomedicines;
transport;
metabolism;
pharmacokinetics;
analytical methods
- From:
Chinese Journal of Pharmacology and Toxicology
2025;39(1):1-13
- CountryChina
- Language:Chinese
-
Abstract:
Peptide nanomedicines have been rapidly developed in the field of tumor treatment and the discovery of new drugs due to their strong stability,precise targeting and high bioavailability.The administration methods of peptide nanomedicines include intravenous injection,oral administration,respiratory administration and transdermal administration,among which intravenous administration is the most commonly used.Once inside the body,peptide nanomedicines can be transported every-where via the blood circulation,accumulating in large quantities at the target site.Effective drug tracking analysis methods can help to obtain accurate pharmacokinetic data,while a comprehensive under-standing of the in vivo distribution and pharmacokinetic characteristics of peptide nanomedicines can contribute to the development of new drugs and promote the progress of cancer therapy.This paper reviews the advantages and disadvantages of analytical methods for peptide nanomedicines and the research progress in their metabolism and transport in order to provide references for subsequent research on peptide nanomedicines.
