Advances of key genes and epigenetic factors during spermatogenesis in non-obstructive azoospermia
10.3760/cma.j.cn101441-20230925-00135
- VernacularTitle:非梗阻性无精子症关键基因及表观遗传因素的研究进展
- Author:
Xiaojun HOU
1
;
Meizi ZHANG
1
;
Fengqin XU
1
Author Information
1. 天津市第一中心医院生殖医学科，天津 300192
- Publication Type:Journal Article
- Keywords:
Spermatogenesis;
Gene;
Meiosis;
Methylation;
Non-coding RNA
- From:
Chinese Journal of Reproduction and Contraception
2024;44(8):872-878
- CountryChina
- Language:Chinese
-
Abstract:
Non-obstructive azoospermia (NOA) is a complex male infertility disease with abnormal spermatogenesis. With the wide application of sequencing technology in recent years, key genes related to spermatogenesis in NOA patients have been continuously mined out. Some epigenetic factors, such as DNA methylation, histone changes and non-coding RNAs are important indicators that reflect to the heterogeneity and complexity of spermatogenesis failure in NOA. This article systematically reviewed the latest studies on the key genes and some epigenetic factors during spermatogenesis of NOA, which may prospectively help to exploit clinical biomarker and to optimize therapeutic proposals.
