Research progress on autoimmune glial fibrillary acidic protein astrocytopathy
10.3969/j.issn.1002-0152.2024.12.009
- VernacularTitle:自身免疫性胶质纤维酸性蛋白星形细胞病研究进展
- Author:
Jiajia JIANG
1
;
Wenxuan WANG
1
;
Yi YANG
1
;
Yajing LIU
1
;
Shuanghao FENG
1
;
Hui BU
1
Author Information
1. 河北医科大学第二医院神经内科(石家庄 050004)
- Publication Type:Journal Article
- Keywords:
Autoimmune glial fibrillary acidic protein astrocytosis;
GFAP-IgG;
Overlapping autoimmune syn-drome;
Tuberculous meningitis;
Encephalitis;
Myelitis
- From:
Chinese Journal of Nervous and Mental Diseases
2024;50(12):753-759
- CountryChina
- Language:Chinese
-
Abstract:
Autoimmune glial fibrillary acidic protein astropathy(GFAP-A)is an autoimmune inflammatory disease of the central nervous system,with a prevalence rate of 0.6 per 100,000.Its clinical manifestations include subacute meningitis,encephalitis,myelitis,or combinations thereof.Approximately 40%of patients exhibit symptoms and signs of prodromal infection such as fever and headache,while 30%may develop tumors.Currently,diagnosis primarily relies on the presence of GFAP-IgG in cerebrospinal fluid.Differential diagnosis must exclude conditions such as central nervous system vasculitis,inflammatory demyelinating diseases,lymphoma,glioma,and brain metastases,posing significant challenges in clinical practice.This paper summarizes the clinical manifestations,diagnosis,and treatment of GFAP-A to enhance understanding of the disease and prevent misdiagnosis.
