Two cases of delayed puberty caused by intracranial germ cell tumors and literature review

VernacularTitle:颅内生殖细胞肿瘤致青春期延迟2例并文献复习
Author: Lingbo XU ¹ ; Xiaotong SUN ; Xiyan HE ; Ruiyang PU ; Jingran ZHEN
Author Information

1. 甘肃省人民医院产科，兰州　730000
Publication Type:Journal Article
Keywords: Germ cell tumors; Delayed puberty; Sex hormones
From: Chinese Journal of Reproduction and Contraception 2024;44(7):739-741
CountryChina
Language:Chinese
Abstract: Intracranial germ cell tumors (iGCT) is a common cause of delayed puberty (DP).　A retrospective analysis was conducted on the clinical data of two patients with DP caused by iGCT. The disease characteristics of the two patients included DP, primary amenorrhea, growth retardation, short stature, subclinical hypothyroidism, etc. They were diagnosed as DP through imaging and related biochemical tests, and some sex hormone drugs were given on the basis of active treatment of the primary disease. Two patients had varying degrees of development in height, weight and secondary sexual characteristics, and further treatment condition is being tracking by us. Early identification and appropriate clinical intervention are of great significance to the reproductive endocrine function, bone health and long-term health such as terminal height of DP patients.