Research progress of renin-angiotensin system in hypertensive depression
- VernacularTitle:肾素-血管紧张素系统在高血压抑郁中的研究进展
- Author:
Lu-fan SHEN
1
;
Xiao-ke WANG
;
Hong WANG
;
Ling-na ZHANG
;
Jia-wei LI
;
Yu-yuan LU
;
Jiao TIAN
;
Wan-rong KANG
;
A-ni YANG
;
Lin YI
Author Information
- Publication Type:Journal Article
- Keywords: renin-angiotensin system; high blood pressure; de-pression; co-morbidity; mechanisms; review
- From: Chinese Pharmacological Bulletin 2025;41(9):1629-1635
- CountryChina
- Language:Chinese
- Abstract: With the establishment of bio-psycho-social medical model,both social and psychological factors play an important role in the occurrence,development and treatment of diseases.Hypertension is a common chronic multiple disease in China,and patients are often complicated with depression and other e-motional disorders.The interaction between hypertension and depression significantly increases the risk of poor prognosis.Current studies have shown a bidirectional promoting relationship between hypertension and depression,and they have some com-mon pathogenesis.However,the specific mechanism of their co-morbidity has not been fully elucidated.Renin-angiotensin sys-tem(RAS)plays an important role in the regulation of hyperten-sion and depression and other emotions.It is composed of two antagonistic pathways.The balance is maintained by angioten-sin-converting enzyme 2(ACE2).Therefore,this article reviews the relationship and mechanism of RAS in hypertension,depres-sion and comorbid states,in order to provide new treatment ide-as for hypertension and depression.
