Association between urinary albumin creatinine ratio and amnestic mild cognitive impairment in elderly patients with type 2 diabetes mellitus
10.3969/j.issn.1002-0152.2024.12.003
- VernacularTitle:老年2型糖尿病患者尿白蛋白/肌酐水平与遗忘型轻度认知功能障碍的相关性研究
- Author:
Ling ZHANG
1
;
Ying WANG
1
;
KANLIBINUER
1
;
Maomao MENG
1
;
Tao XIAN
1
Author Information
1. 新疆维吾尔自治区人民医院综合保健内科(乌鲁木齐 830002)
- Publication Type:Journal Article
- Keywords:
Elderly;
Type 2 diabetes mellitus;
Urinary albumin/creatinine ratio;
Cognitive impairment;
Mild;
Amnestic
- From:
Chinese Journal of Nervous and Mental Diseases
2024;50(12):719-725
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between urinary albumin/creatinine ratio and amnestic mild cognitive impairment(aMCI)in elderly patients with T2DM.Methods From December 2018 to November 2021,a total of 198 elderly patients with T2DM who were hospitalized in the People's Hospital of Xinjiang Uygur Autonomous Region.A variety of neuropsychological scales were used to evaluate cognitive function.The patients were divided into normal cognition(CON)group and aMCI group based on the diagnostic criteria of aMCI according to the level of UACR.The patients were classified into normal proteinuria group,microalbuminuria group and macroalbuminuria group.Results The total score of MMSE showed a decreasing trend in the normal albuminuria group,the microalbuminuria group and the macroalbuminuria group,but the difference was not significant(P>0.05).The scores of recall and delayed recall in the microalbuminuria and macroalbuminuria groups were lower than those in the normal albuminuria group,especially in the macroalbuminuria group(P<0.01).After adjusting covariates,multivariate logistic regression analysis showed that microalbuminuria(OR=1.35,95%CI:11.16-4.95)and macroalbuminuria(OR=4.38,95%CI:1.68-11.87)were still associated with higher risk of aMCl.Conclusion UACR is associated with an increased risk of amnestic mild cognitive impairment in elderly patients with T2DM.
