Dual regulation mechanism, clinical value of lncRNA in PCOS and intervention role of Traditional Chinese Medicine
10.3760/cma.j.cn101441-20240829-00320
- VernacularTitle:LncRNA在多囊卵巢综合征中的双重调控机制、临床价值及中医药干预研究现状
- Author:
Baosong LIU
1
;
Caixia LI
;
Yingying SUN
;
Xiaofang ZHANG
;
Mengfan PENG
Author Information
1. 驻马店市中医院药学部，驻马店 463000
- Publication Type:Journal Article
- Keywords:
Polycystic ovary syndrome;
Long noncoding RNA;
Biomarkers;
Traditional Chinese Medicine
- From:
Chinese Journal of Reproduction and Contraception
2025;45(1):77-84
- CountryChina
- Language:Chinese
-
Abstract:
Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disorder in women of childbearing age, which can cause metabolic disorders, cardiovascular disease, ovarian cancer, uterine cancer and other complications, seriously endangering the health of the body. China has become one of the countries with the fastest increasing prevalence of PCOS, but its complex pathogenesis leads to highly heterogeneous clinical manifestations, making it difficult to completely cure. Therefore, clarifying the potential pathogenesis of PCOS is of great significance for early clinical screening, diagnosis, treatment, and prognosis. Recent studies have shown that long noncoding RNA (lncRNA) plays a dual role in the pathogenesis of PCOS and is a potential novel biomarker and intervention target. The characteristics of multi-component, multi-target, and multi-pathway action in Traditional Chinese Medicine (TCM) are consistent with the biological properties of lncRNA, which have diverse types, dual roles, and diverse locations. However, research on lncRNA mediated PCOS and how TCM can improve PCOS by regulating lncRNA is relatively scattered, which is not conducive to the recognition of its clinical value. Therefore, this article provides a systematic review of the dual regulatory mechanism, clinical value, and TCM intervention research of lncRNA in the occurrence and development of PCOS, aiming to clarify how lncRNA affects the occurrence and development of PCOS and potential treatment strategies, in order to provide new ideas for the clinical prevention and treatment of PCOS.
