Research progress of macrophage polarization in ovarian aging
10.3760/cma.j.cn101441-20240122-00034
- VernacularTitle:巨噬细胞极化在卵巢衰老中的研究进展
- Author:
Danping LI
1
;
Wenhan JU
;
Fang LIAN
;
Shan XIANG
Author Information
1. 山东中医药大学第一临床医学院，济南 250014
- Publication Type:Journal Article
- Keywords:
Inflammation;
Ovarian senescence;
Ovarian reserve;
Macrophage polarization;
Regulating pathways
- From:
Chinese Journal of Reproduction and Contraception
2024;44(10):1075-1079
- CountryChina
- Language:Chinese
-
Abstract:
Macrophages are the most abundant immune cells in the ovary. They participate in the innate immune response and play an important role in ovarian physiological processes such as follicle formation, ovulation, luteal formation and regression, as well as in maintaining ovarian homeostasis. Macrophages can be polarized into M1/M2 type, which can respond to senescence specific signals in the ovarian aging microenvironment, participate in the ovarian aging process, and play different roles in ovarian aging. This article reviews the polarization regulation pathway of macrophages, the physiological role of macrophages in normal ovarian function, and the impact of macrophage polarization on ovarian aging.
