Research Progress of Magnetic Resonance Imaging in Predicting Cytokeratin 19-Positive Hepatocellular Carcinoma
10.3969/j.issn.1005-5185.2024.12.020
- VernacularTitle:MRI预测CK19阳性肝细胞癌的研究进展
- Author:
Qian WANG
1
;
Jinkui LI
;
Junxia XU
;
Shunmin ZHAO
;
Junqiang LEI
Author Information
1. 兰州大学第一临床医学院,甘肃 兰州 730000;兰州大学第一医院放射科,甘肃 兰州 730000
- Publication Type:Journal Article
- Keywords:
Carcinoma,hepatocellular;
Keratin-19;
Magnetic resonance imaging;
Radiomics;
Review
- From:
Chinese Journal of Medical Imaging
2024;32(12):1300-1304
- CountryChina
- Language:Chinese
-
Abstract:
Cytokeratin 19 (CK19) is a molecular marker of hepatic stem cells and bile duct cells. Studies have indicated that the expression of CK19 plays a key role in chemotherapeutic resistance/stem cell immunophenotype of hepatocellular carcinoma (HCC),which indicates a poor prognosis. Therefore,accurate identification of the expression of CK19 in HCC before treatment can provide important information for the choice of treatment in the future. MRI plays an important role in the diagnosis,staging and prognosis assessment of HCC. Radiomics can extract a large number of high-dimensional quantitative features from multimodal medical images,which is helpful to evaluate CK19 more objectively. This article reviews the research progress and prospect of imaging in the diagnosis of CK19-positive HCC in recent years.
