Research progress on the role of HSP70 in early embryonic development

VernacularTitle:HSP70在早期胚胎发育中作用的研究进展
Author: Xiangyang OU ¹ ; Jinli DING ¹ ; Zhe YANG ¹ ; Qixuan ZHANG ¹ ; Gengxiang WU ¹
Author Information

1. 武汉大学人民医院生殖医学中心，武汉　430060
Publication Type:Journal Article
Keywords: Heat shock protein 70; Zygote; Embryo implantation; Early embryonic development
From: Chinese Journal of Reproduction and Contraception 2024;44(11):1196-1199
CountryChina
Language:Chinese
Abstract: Heat shock proteins (HSPs) are a group of highly conserved and functionally diverse molecular chaperones that play a crucial role in maintaining cellular homeostasis and coping with a variety of stress responses. HSP70 is one of the important members of the HSPs family, which is involved in the correct folding of proteins, preventing aggregation, and plays a key role in the formation of germ cells, DNA damage repair, fertilization process and embryo implantation in early embryonic development. HSP70 maintains the healthy development of embryos and protects cells from injury under various stress conditions by promoting the normal development and cellular homeostasis of fertilized eggs after fertilization. Through in-depth study of the complex functions and potential mechanisms of HSP70, it is expected to reveal its role in unexplained infertility, recurrent implantation failure, recurrent abortion and other diseases.