Research progress on anti-inflammatory activity of cannabidiol and its derivatives
- VernacularTitle:大麻二酚及其衍生物的抗炎活性研究进展
- Author:
Peng-yu CHEN
1
;
Zhao ZHANG
;
Nai-hong CHEN
Author Information
- Publication Type:Journal Article
- Keywords: cannabidiol; cannabidiol derivatives; anti-inflam-matory activity; targets; structural modification; structure-activi-ty relationship
- From: Chinese Pharmacological Bulletin 2025;41(9):1613-1617
- CountryChina
- Language:Chinese
- Abstract: Cannabidiol(CBD),a major pharmacologically active phytocannabinoid found in cannabis,exhibits potent anti-inflam-matory activity through its multi-target actions.Furthermore,CBD derivatives with enhanced activity through structural modifi-cations are gaining increasing attention for their potential thera-peutic benefits.While reviews have explored the targets and pharmacological effects of CBD and its derivatives,and the struc-ture-activity relationship(SAR)of cannabinoid quinones regard-ing anticancer activity,a systematic summary of the SAR of CBD and its derivatives concerning anti-inflammatory activity is cur-rently lacking.This review therefore summarizes the research progress on the anti-inflammatory activity of CBD and its deriva-tives,focusing on their mechanisms of action,the impact of dif-ferent structural modifications on anti-inflammatory activity,and their potential applications in the treatment of inflammatory dis-eases.
