Research progress in roles of IL-6 in viral infection

VernacularTitle:IL-6在病毒感染中作用的研究进展
Author: Yan WANG ¹ ; Wan-ning GAO ; Shuai SHAO ; Yi-yang FAN ; Xiao-lan JI ; De-rong ZHANG ; Jia-lin BAI
Author Information

1. 西北民族大学细胞基质疫苗关键技术与产业化教育部工程研究中心,兰州 730030;西北民族大学生物医学研究中心生物工程与技术国家民委重点实验室,兰州 730030;西北民族大学甘肃省动物细胞技术创新中心,兰州 730030;西北民族大学生命科学与工程学院,兰州 730030
Publication Type:Journal Article
Keywords: interleukin-6; viral infection; cytokine storm; signaling pathway
From: Chinese Journal of Zoonoses 2024;40(12):1182-1187
CountryChina
Language:Chinese
Abstract: Interleukin 6,a cytokine secreted in innate immune resistant virus infection,has recently attracted widespread attention because of its effects in cytokine storms.High IL-6 levels have been shown to effectively suppress viral infections,but experiments increasingly indicate that excessive IL-6 secretion in complex immune responses in the body is not only counterpro-ductive but also causes severe damage to the body.This article reviews current research progress in the roles of IL-6 in hepatitis B virus,influenza A virus,respiratory syncytial virus,severe acute respiratory syndrome coronavirus 2,rotavirus,and en-cephalomyocarditis virus infections,to provide new ideas and approaches for blocking viral infection and developing new antivi-ral drugs.