Research progress on role of CRY1/2 in regulation of glucose and lipid metabolism
10.12360/CPB202502003
- VernacularTitle:CRY1/2在糖脂代谢调控中的作用研究进展
- Author:
Yu-tong CHEN
1
;
Zhi-qiang ZHAO
1
;
Yong-bin TONG
1
;
Yu-yu LIU
1
Author Information
1. 广东医科大学药学院,广东东莞 523808
- Publication Type:Journal Article
- Keywords:
CRY1/2;
glucose metabolism;
lipid metabolism;
insulin resistance;
obesity;
regulatory mechanisms
- From:
Chinese Pharmacological Bulletin
2025;41(9):1607-1612
- CountryChina
- Language:Chinese
-
Abstract:
CRY1/2,as important transcriptional regulators of the circadian clock system,play a crucial role in maintaining metabolic homeostasis in body.This article analyzes existing re-search and focuses on the regulatory mechanisms of CRY1/2 in glucose and lipid metabolism.CRY1 plays an important regula-tory role in gluconeogenesis,glycolysis and insulin secretion,maintaining blood glucose homeostasis by regulating the expres-sion of key enzymes.Additionally,CRY1/2 regulate lipid me-tabolism by modulating fat synthesis and absorption,thereby af-fecting energy balance in the body.This article also discuss the potential applications of CRY1/2 in obesity and xenobiotic de-toxification,highlighting their potential value as therapeutic tar-gets.As core factors in metabolic regulation,CRY1/2 have sig-nificant clinical application prospects,and a deeper understand-ing of their molecular mechanisms in glucose and lipid metabo-lism will provide new ideas and strategies for the treatment of chronic metabolic diseases.
