Epigenetic modifications in kidney disease:from functional resolution to clinical application
10.12360/CPB202503014
- VernacularTitle:肾脏疾病中的表观遗传修饰:从功能解析到临床转化
- Author:
Meng-meng ZHANG
1
;
Xiao-guo SUO
;
Qing-lin GE
;
Chao LI
;
Jia-nan WANG
;
Xiao-ming MENG
Author Information
1. 安徽医科大学药学科学学院;合肥市口腔医院
- Publication Type:Journal Article
- Keywords:
kidney disease;
epigenetic modification;
epigenetic therapeutic strategies;
diagnostic markers;
clinical application;
future strategies
- From:
Chinese Pharmacological Bulletin
2025;41(9):1601-1607
- CountryChina
- Language:Chinese
-
Abstract:
Advances in genomics,biochemistry,and genetics have deepened our understanding of epigenetic mechanisms.These mechanisms play a crucial role in life,heredity,and evo-lution.Their growing significance is driving biomedical research toward personalized and precise medicine.Renal diseases,par-ticularly chronic kidney disease and acute kidney injury,require new treatment strategies.Their subtle clinical symptoms and challenges in early diagnosis limit current therapeutic options.Research on epigenetic modifications in renal diseases is expan-ding rapidly.This field is emerging as a promising approach for kidney disease treatment.The transition from basic mechanistic studies to clinical applications is underway.Epigenetic modifica-tions hold great potential for improving early diagnosis,enabling personalized treatment,and advancing precision medicine in re-nal diseases.
