Advances in quantitative determination methods and pharmacoki-netics of melatonin and its metabolites
10.3867/j.issn.1000-3002.2025.02.007
- VernacularTitle:褪黑素及其代谢物的定量检测方法和药动学研究进展
- Author:
Mengran WANG
1
;
Xiaomei ZHUANG
Author Information
1. 军事医学研究院,北京 100850;华北理工大学药学院,河北 唐山 063509
- Publication Type:Journal Article
- Keywords:
melatonin;
liquid chromatography-tandem mass spectrometry(LC-MS/MS);
pharma-cokinetics;
drug metabolism;
drug-drug interactions;
bioavailability
- From:
Chinese Journal of Pharmacology and Toxicology
2025;39(2):138-145
- CountryChina
- Language:Chinese
-
Abstract:
Sleep disorders are becoming a social problem that poses a danger to human health and an obstacle to economic development.As an endogenous hormone,melatonin plays an important role in regulating circadian rhythm.Research has shown that exogenous melatonin holds promising prospects in the treatment of insomnia disorders and thus merits in-depth exploration and development.Given the close relationship between pharmacokinetic properties and drug efficacy as well as toxicity,this paper reviews the quantitative analysis methods for melatonin and its major metabolites,especially the pretreatment methods for biological samples and the related LC-MS/MS analysis methods.Studies related to the absorption,distribution,metabolism,excretion and drug-drug interactions of melatonin both in vivo and in vitro,as well as the level and species differences of endogenous melatonin are also outlined.Meanwhile,the druggability of melatonin and corresponding solutions are explored in the hope of providing data for the development of exogenous melatonin into novel sleep-regulating drugs.
