Research Progress on Application of cGAS-STING Signaling Pathway in Colorectal Cancer
10.3969/j.issn.1008-7125.2024.12.007
- VernacularTitle:cGAS-STING信号通路在结直肠癌中的应用研究进展
- Author:
Dehong KONG
1
;
Zilong LIU
;
Jianjun HU
;
Xun LONG
;
Zhuxue ZHANG
;
Jiemin LIU
Author Information
1. 遵义医科大学研究生院(563006)
- Publication Type:Journal Article
- Keywords:
cGAS-STING;
Colorectal Neoplasms;
Immunotherapy
- From:
Chinese Journal of Gastroenterology
2024;29(12):737-744
- CountryChina
- Language:Chinese
-
Abstract:
cGAS-STING signaling pathway is a key signaling molecule of innate immune response in vivo,which can recognize exogenous and endogenous dsDNA abnormalities in cytoplasm and promote the release of immune mediators such as interferon(IFN)-1,thus leading to immune response in the body.Recent studies have suggested that the disturbance of cGAS-STING signal is an important factor in the occurrence and development of colorectal cancer,which can promote tumor growth and metastasis.cGAS-STING signaling is also related to intestinal immune response,and the use of this signaling pathway helps to provide a new target for colorectal cancer immunotherapy.This article reviewed the role of cGAS-STING signaling pathway in the occurrence and development of colorectal cancer and the latest research progress,the application of cGAS-STING signaling pathway modulators and their combined therapy in colorectal cancer,and forecast the future research direction of this signaling pathway in the treatment of colorectal cancer.
