Research progress on the mechanism of endometrial immune inflammation microenvironment regulating embryo implantation
10.3760/cma.j.cn101441-20231122-00324
- VernacularTitle:子宫内膜免疫炎症微环境调控胚胎种植的机制研究进展
- Author:
Chunlei WU
1
;
Xiaoli ZHAO
1
;
Rong DONG
1
;
Baojuan WANG
1
;
Yunhuan QIU
1
;
Tian XIA
1
Author Information
1. 天津中医药大学第一附属医院生殖医学科 国家中医针灸临床医学研究中心，天津 300193
- Publication Type:Journal Article
- Keywords:
Embryo implantation;
Blastocyst activation;
Endometrial receptivity;
Immune-inflammatory microenvironment
- From:
Chinese Journal of Reproduction and Contraception
2024;44(9):986-989
- CountryChina
- Language:Chinese
-
Abstract:
The endometrial immune inflammatory microenvironment, composed of immune cells and cytokines, exhibits acute, low-grade, and transient pro-inflammatory characteristics during the embryo implantation window period. During this period, implantation capability is achieved by regulating blastocyst activation, promoting the endometrium to establish a receptive state, and mediating the positioning, adhesion, and invasion of the embryo. Abnormalities in the number and proportion of endometrial immune cells were associated with embryo implantation failure and altered characteristics of the immunoinflammatory microenvironment led to embryo implantation failure. The research progress on the mechanism of endometrial immunoinflammatory microenvironment regulating embryo implantation is now reviewed.
