Application efficacy of Kuntai capsules combined with PPOS regimen for expected poor ovarian response patients undergoing IVF/ICSI cycles: a retrospective cohort study
10.3760/cma.j.cn101441-20231205-00352
- VernacularTitle:坤泰胶囊联合PPOS方案在IVF/ICSI预期卵巢低反应患者中的应用疗效：一项回顾性队列研究
- Author:
Lingling HUANG
1
;
Qiqi XIE
1
;
Leizhen XIA
1
;
Lifeng TIAN
1
;
Dingfei XU
1
;
Huijun ZUO
1
;
Mengxi LI
1
;
Yunjun LI
1
;
Ke ZHANG
1
;
Qiongfang WU
1
;
Jialyu HUANG
1
Author Information
1. 江西省妇幼保健院生殖医学中心，南昌330000
- Publication Type:Journal Article
- Keywords:
Fertilization invitro;
Kuntai capsules;
Progestin-primed ovarian stimulation;
Poor ovarian response
- From:
Chinese Journal of Reproduction and Contraception
2024;44(9):916-921
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effect of Kuntai capsules combined with progestin-primed ovarian stimulation (PPOS) protocol on the ovarian response, laboratory parameters and embryo transfer outcomes of expected poor ovarian response (POR) patients undergoing invitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycles. Methods:A retrospective cohort study was performed at Center for Reproductive Medicine, Jiangxi Maternal and Child Health Hospital from June 2020 to July 2023. A total of 1 733 expected POR patients were enrolled and divided into the PPOS only group (control group) and the Kuntai capsules combined with PPOS regimen group (trial group). After a 1∶1 propensity score matching, 423 cases were included in each group. Further analyses and comparisons were made between the two groups, concerning the ovarian stimulation outcomes, embryo laboratory parameters and pregnancy rates after the first frozen-thawed embryo transfer cycles. The primary outcome measure was the number of oocytes retrieved.Results:No statistically significant difference was found in baseline characteristics after matching between the two groups (all P>0.05). Compared with control group, the number of oocytes retrieved did not differ significantly in the trial group ( P=0.295). The level of luteinizing hormone (LH) on the trigger day [3.3 (2.2, 5.0) U/L], the number of available blastocysts formed [1 (0, 1)] and the available blastocyst formation rate [46.2% (85/184)] in the trial group were significantly higher than those in control group [2.9 (1.9, 4.5) U/L, P=0.004; 0 (0, 1), P=0.034; 30.0% (48/160), P=0.002]. However, there were no significant differences in the duration and dosage of gonadotropin used, progesterone and estradiol levels on the trigger day, incidence of premature LH surge, number/rate of fertilized oocytes, number/rate of cleaved embryos, number/rate of high-quality embryos, as well as rate of unavailable embryos (all P>0.05). Compared with control group, the trial group demonstrated comparable implantation rate, clinical pregnancy rate, early miscarriage rate, ongoing pregnancy rate and live birth rate after the first frozen-thawed embryo transfer cycles (all P>0.05). Conclusion:Compared with the PPOS only regimen, the combination of Kuntai capsules and PPOS did not increase the number of oocytes retrieved but could increase the number and rate of available blastocysts formed in expected POR patients.
