Quantitative Analysis of Urate Deposition via Dual-Energy Spectrum CT in Acute Gouty Knee Osteoarthritis with Correlation to Hematology Indices
10.3969/j.issn.1005-5185.2025.02.016
- VernacularTitle:双能量能谱CT定量分析尿酸盐沉积对急性痛风性膝关节炎与血液学指标的相关性
- Author:
Hongyang MA
1
;
Li LIU
;
Wei ZHONG
;
Honggang LIU
;
Hongyan MENG
;
Yanming LIANG
Author Information
1. 牡丹江医学院,黑龙江 牡丹江 157000
- Publication Type:Journal Article
- Keywords:
Arthritis,gouty;
Knee joint;
Energy spectrum CT;
Radiography,dual-energy scanned projection;
Lymphocyte count;
Neutrophils;
Blood platelets
- From:
Chinese Journal of Medical Imaging
2025;33(2):192-196,204
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To explored the correlation between imaging features and patient's blood markers based on quantitative analysis of urate deposition in acute exacerbations of gouty arthritis of the knee by dual-energy spectrum CT(DECT).Materials and Methods A retrospective analysis was conducted on energy spectrum CT imaging of 72 patients clinically diagnosed with acute gouty knee osteoarthritis and 87 patients with non-gouty knee disease during the acute exacerbation period at the First Hospital of Qiqihar from January 2020 to September 2023.The analysis aimed to evaluate urate deposition in different parts of the knee joints and to analyze the influencing factors of urate deposition combined with the blood test indexes of the patients via receiver operating characteristic curves.Results The neutrophil lymphocyte ratio showed a positive correlation with C-reactive protein,erythrocyte sedimentation rate,and urate concentration at the site of urate deposition in gouty nodules of the knee(r=0.354,0.326,0.260,respectively,all P<0.05).The mean platelet volume was significantly positive correlated with the semi-quantitative data of monosodium urate crystals and urate concentration in the knee(r=0.563,0.257,respectively,P<0.05).In the gout group,C-reactive protein was positively correlated with pararticular soft tissue urate concentration and bone urate concentration(r=0.498,0.166,P<0.05),while erythrocyte sedimentation rate was positively correlated with pararticular soft tissue(tendons,ligaments,etc)urate concentration(r=0.325,P<0.01).Additionally,serum uric acid was positively correlated with gouty nodules in the knee joints and pararticular soft tissue(tendons,ligaments,etc)(r=0.264,0.243,respectively,P<0.05).The cut-off values of neutrophil lymphocyte ratio,platelet lymphocyte ratio and mean platelet volume combined with dual-energy energetic spectroscopic CT imaging data in the diagnosis of gouty knee osteoarthritis points were 2.190,122.96 and 9.049,respectively.Conclusion Energetic spectrum CT can identify and quantify urate crystals at the early stage.And blood test indexes such as mean platelet volume,erythrocyte sedimentation rate and serum uric acid have potential value in evaluating the activity of gout and the degree of migration of the disease in gouty knee osteoarthritis.
