Analysis of Changes in Key Nuclei of Dopamine System in Early Parkinson's Disease via Free Water Imaging
10.3969/j.issn.1005-5185.2025.02.003
- VernacularTitle:自由水成像探究早期帕金森病多巴胺系统关键核团的改变
- Author:
Jinyi ZHENG
1
;
Yu SHEN
;
Kaiyue DING
;
Wei WEI
;
Yan BAI
;
Meiyun WANG
Author Information
1. 新乡医学院河南省人民医院医学影像科,河南 郑州 450003;河南省人民医学影像科,河南 郑州 450003
- Publication Type:Journal Article
- Keywords:
Parkinson's disease;
Diffusion tensor imaging;
Free water imaging;
Substantia nigra;
Ventral tegmental area
- From:
Chinese Journal of Medical Imaging
2025;33(2):121-126
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the changes of free water(FW)values in the key basal ganglia of dopamine system in the brain of early Parkinson's disease(PD)by free water imaging,and to reveal the potential relationship between the changes and early PD.Materials and Methods From February to December 2023,62 patients with early PD and 27 healthy controls were enrolled in the Parkinson's Disease Progression Markers Project database,and 25 age-and sex-matched healthy controls were self-recruited from Henan Provincial People's Hospital.All subjects underwent clinical scale assessment and MRI data collection.Free water imaging was used to calculate the FW values of key nuclei in dopamine system,and the difference of FW values between PD group and healthy controls group,the correlation between FW values of PD group and clinical scale scores were analyzed.Results The FW values of compact part of substantia nigra(SNc)and ventral tegmental area(VTA)in PD group were significantly higher than those in healthy controls group(Z=2.458-3.914,all P<0.05).Regression analysis showed that FW values of SNc were correlated with the movement disorder society-sponsored revision unified Parkinson′s disease rating scale(MDS-UPDRS)Ⅲ scores and state-trait anxiety inventory(STAI)scores on both sides(r2=0.223,P<0.001;r2=0.125,P=0.018;r2=0.151,P=0.003;r2=0.128,P=0.017),the FW value of VTA on the left was significantly correlated with MDSUPDRS Ⅲ score(r2=0.143,P=0.004)and the FW value of the right VTA was significantly correlated with the STAI score(r2=0.125,P=0.019).Conclusion The FW values of SNc and VTA in PD patients are significantly increased in the early stage,and are correlated with motor and non-motor symptoms in PD patients.FW values may reflect brain degeneration,and this change may be related to the decline of motor and non-motor function in patients.
