Research progress in nanomaterials induced mitochondrial biogenesis dysfunction and mechanism
10.3867/j.issn.1000-3002.2025.02.006
- VernacularTitle:纳米材料对线粒体生物合成的影响及其机制研究进展
- Author:
Chang XU
1
;
Xiaoya YANG
;
Jiabin GUO
;
Yujie LI
Author Information
1. 中国人民解放军疾病预防控制中心,北京 100071;中国医科大学公共卫生学院,辽宁 沈阳 110001
- Publication Type:Journal Article
- Keywords:
nanomaterials;
mitochondrial biogenesis;
toxicity;
mechanism
- From:
Chinese Journal of Pharmacology and Toxicology
2025;39(2):129-137
- CountryChina
- Language:Chinese
-
Abstract:
Nanomaterials have been used in a variety of industries recently,involving foods,chemi-cals and biomedicine.There are multiple routes through which humans are exposed to nanomaterials,and their toxic effects deserve more attention.In vivo studies have confirmed that nanomaterials expo-sure can lead to toxicity in such target organs as the heart,liver,kidney,skin and nerve.The toxicity mechanism is related to changes in organelles such as the endoplasmic reticulum,lysosomes and mito-chondria.Increasing studies suggest that mitochondria are critical targets for the toxicity of nanomaterials.Mitochondrial biogenesis serves as an important mechanism for maintaining mitochondrial homeostasis,which plays a vital role in the process of nanomaterials-induced cellular toxicity.This article summarizes the current research on the effects of nanomaterials on mitochondrial biogenesis,and elaborates the mechanism through which nanomaterials disrupt mitochondrial biogenesis by triggering oxidative stress,upsetting the homeostasis of calcium ion and disturbing toxicity pathways.This article is expected to provide a reference for toxicity testing and risk assessment of nanomaterials.
