Research progress on the role of the cGAS-STING signaling pathway in the pathogenesis of glaucoma and its targeted therapeutic strategies
10.13389/j.cnki.rao.2025.0129
- VernacularTitle:cGAS-STING信号通路在青光眼发病机制中的作用及其靶向治疗策略的研究进展
- Author:
Xiaojuan HUANG
1
;
Jin ZHANG
;
Hongyun YUE
Author Information
1. 730050 甘肃省兰州市,联勤保障部队第九四○医院眼科
- Publication Type:Journal Article
- Keywords:
cyclic GMP-AMP synthase-stimulator of interferon genes signaling pathway;
glaucoma;
cGAS small-mole-cule inhibitor;
STING inhibitor
- From:
Recent Advances in Ophthalmology
2025;45(9):752-756
- CountryChina
- Language:Chinese
-
Abstract:
Glaucoma is a blinding eye disease characterized by optic nerve damage and visual field defects,with a complex pathogenesis.Studies have shown that the abnormal activation of the cyclic GMP-AMP synthase-stimulator of in-terferon genes(cGAS-STING)signaling pathway may be closely related to the occurrence and development of glaucoma.New therapeutic strategies targeting this pathway,such as the cGAS small-molecule inhibitor RU.521 and the STING inhibi-tor H-151,have been shown to effectively alleviate pathological changes associated with glaucoma,and research into their mechanisms of action is becoming increasingly in-depth.This article aims to review the basic mechanisms of the cGAS-STING signaling pathway and its role in the pathogenesis of glaucoma,as well as the latest research progress of compounds targeting cGAS and STING in the treatment of glaucoma,in order to provide a new perspective for the immunotherapy of glaucoma.
