Research progress on the role of AMP-activated protein kinase in ocular dis-eases
10.13389/j.cnki.rao.2025.0126
- VernacularTitle:腺苷酸活化蛋白激酶在眼病中的作用研究进展
- Author:
Ruping WANG
1
;
Pubo WANG
;
Xiuzhen LU
;
Qiuxin WU
Author Information
1. 250014 山东省济南市,山东中医药大学眼科与视光医学院
- Publication Type:Journal Article
- Keywords:
adenosine monophosphate-activated protein kinase;
metabolism regulation;
autophagy;
mitochondrial function;
ophthalmic diseases
- From:
Recent Advances in Ophthalmology
2025;45(9):731-737
- CountryChina
- Language:Chinese
-
Abstract:
Adenosine monophosphate-activated protein kinase(AMPK),acting as a"molecular switch"for cellular energy status,regulates multiple metabolic pathways to maintain energy balance and plays a crucial role in the development of various ocular diseases.This article summarizes the mechanisms of AMPK in several ophthalmic diseases and the pro-gress of related research,with a focus on age-related macular degeneration,diabetic retinopathy,and ocular surface disea-ses.By reviewing the pathogenesis of these diseases and the regulatory role of the AMPK signaling pathway,we explore the potential applications of the AMPK signaling pathway in the treatment of ophthalmic diseases and analyze the limitations and deficiencies of current research.With further investigation,regulatory strategies targeting the AMPK signaling pathway are expected to provide new ideas and potential therapies for the treatment of ophthalmic diseases in the future.
