Pathological calcification in temporomandibular joint osteoarthritis:Mechanisms and targeted therapeutic strategies
10.13591/j.cnki.kqyx.2025.08.001
- VernacularTitle:颞下颌关节骨关节炎病理性钙化机制及精准防治策略
- Author:
Xiaoxiao HAN
1
;
Wenpin QIN
1
;
Kai JIAO
1
Author Information
1. 空军军医大学唐都医院口腔科,陕西西安(710038)
- Publication Type:Journal Article
- Keywords:
pathological calcification;
osteoarthritis;
chondrocyte;
calcified vesicles
- From:
STOMATOLOGY
2025;45(8):561-566
- CountryChina
- Language:Chinese
-
Abstract:
Temporomandibular joint osteoarthritis(TMJ-OA)is a chronic disorder characterized by degeneration of articular cartilage,pain,and functional impairment,with pathological calcification serving as a central pathological hallmark closely associated with dis-ease progression.Recent studies have demonstrated that pathological calcification accelerates joint destruction by altering cartilage bio-mechanical properties,activating inflammatory responses,and promoting matrix degradation pathways.This review systematically re-views the critical role of pathological calcification in the pathogenesis of temporomandibular joint osteoarthritis(TMJ-OA),with a focus on molecular mechanisms including key signaling pathways,autophagy-derived calcifying vesicles,lysosomal destabilization and organ-elle crosstalk.It further summarizes novel intervention strategies such as pharmacological treatments,gene therapy,and nanotechnology-based approaches,thereby providing a theoretical foundation for the precise prevention and treatment of TMJ-OA.
