Correlation Between Aortic Dilation and Left Ventricular Myocardial Work in Well-Functioning Bicuspid Aortic Valves Malformation via Left Ventricular Pressure-Strain Ring
10.3969/j.issn.1005-5185.2025.02.008
- VernacularTitle:基于左心室压力-应变环评估功能正常的二叶式主动脉瓣畸形患者主动脉病变与左心室心肌做功的相关性
- Author:
Liming WANG
1
;
Nan WU
;
Lili WANG
;
Lisha NA
Author Information
1. 宁夏医科大学总医院心脏中心功能部,宁夏 银川 750004;西安市中医医院功能科,陕西 西安 710000
- Publication Type:Journal Article
- Keywords:
Bicuspid aortic valve disease;
Echocardiography;
Pressure-strain loop;
Myocardial work;
Aortic dilation
- From:
Chinese Journal of Medical Imaging
2025;33(2):152-157
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To quantitatively evaluate the change of left ventricular myocardial work in well-functioning bicuspid aortic valves(BAV)by using left ventricular pressure-strain ring technology,and to explore the correlation between aortic dilation and myocardial work.Materials and Methods A total of 65 patients with well-functioning BAVs admitted to General Hospital of Ningxia Medical University from June 2022 to June 2023 were selected and divided into two groups according to the adjusted inner diameter of the aorta by body surface area:aortic undilated group(35 cases,theaortic diameter<40 mm or aortic size index<22 mm/m2)and aortic dilation group(30 cases,aortic diameter≥40 mm or aortic size index>22 mm/m2),34 healthy patients were enrolled in our study as the control group.The study subjects were analyzed by echocardiography to obtain the left ventricular myocardial work[global longitudinal strain(GLS),global work index(GWI),global constructive work(GCW),global work efficiency(GWE),global wasted work(GWW)]and conventional two-dimensional ultrasound parameters,and the parameters between the three groups were compared and analyzed.Results Compared with the control group,the absolute value of GLS and GWE in the non-dilated aortic group and the aortic dilated group decreased,and the GWI,GCW,GWW,ascending aortic inner diameter and ascending aortic stiffness index were significantly increased(P<0.05).Compared with the non-dilated aortic group,the absolute value of GLS and GWE in the aortic dilation group decreased,and the aortic stiffness index and GWW increased,and the difference was statistically significant(t=-3.567,-2.219,5.266,3.339,all P<0.05).The internal diameter of the ascending aorta was negatively correlated with the absolute value of GLS and GWE(r=-0.219,-0.324,both P<0.001),and positively correlated with GWI,GCW,GWW and ascending aortic stiffness index(r=0.178,0.229,0.315,0.529,all P<0.001).Conclusion Myocardial work is a new method for early detection of subclinical left ventricular myocardial dysfunction in well-functioning BAV,and has potential application value for evaluating the changes in left ventricular myocardial work under the progression of aortic disease in BAV patients.
