Progress on endocrine disruptors affecting testicular 3β-hydroxysteroid dehydrogenase and their mechanism of action
10.3760/cma.j.cn101441-20231208-00356
- VernacularTitle:影响睾丸3β-羟基类固醇脱氢酶的内分泌干扰物及其作用机制进展
- Author:
Chengshuang PAN
1
;
Peiyu WANG
;
Qianjin FEI
;
Renshan GE
Author Information
1. 温州医科大学附属第一医院生殖中心, 温州 325000
- Publication Type:Journal Article
- Keywords:
3β-hydroxysteroid dehydrogenase;
Testosterone synthesis;
Steroidogenesis;
Environmental endocrine disruptors;
Polyphenols;
Phthalates
- From:
Chinese Journal of Reproduction and Contraception
2024;44(6):602-609
- CountryChina
- Language:Chinese
-
Abstract:
3β-hydroxysteroid dehydrogenase (3β-HSD) is a steroidogenic enzyme that catalyzes the conversion of 3β-hydroxysteroids to 3-ketosteroids. Two different subtypes of human 3β-HSD, HSD3B1 and HSD3B2, have been cloned, with HSD3B2 primarily expressed in the testes. HSD3B2 exhibits 3β-HSD2 activity and is a dual-substrate enzyme that binds with co-factors NAD + and 3β-steroids. Many endocrine disruptors, including industrial compounds (phthalates, bisphenols, perfluoroalkyl substances, and benzophenones), pesticides and fungicides (organochlorine pesticides and organotins), food additives (butylated hydroxyanisole, resveratrol, gossypol, flavonoids and isoflavonoids, curcuminoids, and chalcones), and drugs (etomidate, mifepristone, and ketoconazole) inhibit testicular 3β-HSD, potentially interfering with androgen synthesis. In this review, we summarized the unique testicular subtypes of 3β-HSD, their genes, chemistry, subcellularity, location, and the endocrine disruptors that directly inhibit testicular 3β-HSD and their modes of inhibition, to provide reference for clinical research on androgen regulation methods and the development of androgen-targeted drugs.
