The Relationship between Serum Histone Deacetylase-3 and the Severity of En-dometriosis
- VernacularTitle:血清组蛋白脱乙酰化酶-3与子宫内膜异位症严重程度的关系
- Author:
XinYue ZHANG
1
;
Xiaoxia ZHANG
;
Jianjun LU
Author Information
1. 内蒙古医科大学附属医院妇产科,内蒙古呼和浩特 010059;内蒙古自治区妇产疾病临床医学研究中心妇产科,内蒙古呼和浩特 010059
- Publication Type:Journal Article
- Keywords:
Endometriosis;
Severity of the disease;
Histone deacetylase-3;
Correlation
- From:
Journal of Practical Obstetrics and Gynecology
2025;41(8):678-682
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between serum histone deacetylase-3(HDAC3)and the severity of endometriosis(EMT).Methods:The clinical data of 109 EMT patients admitted to the Affiliated Hospi-tal of Inner Mongolia Medical University from June 1,2021 to November 30,2023 were extracted and analyzed.Pa-tients were divided into stage Ⅰ/Ⅱ group(56 cases)and stage Ⅲ/Ⅳ group(53 cases)according to the revised EMT staging criteria of the American Society for Reproductive Medicine(ASRM).Univariate analysis and binary Logistic regression were used to analyze the correlation factors between serum HDAC3 and the severity of EMT patients,and receiver operating characteristic(ROC)curve was plotted and the area under the curve(AUC)was calculated to evaluate the diagnostic value of stage Ⅲ/Ⅳ EMT.Results:The levels of serum HDAC3,human epididymal protein 4(HE4),serum carbohydrate antigen 125(CA125),vascular endothelial growth factor(VEGF),platelet to lymphocyte count ratio(PLR),and fibrinogen(Fib)in stage Ⅲ/Ⅳ patients were significantly higher than those in stage Ⅰ/Ⅱ patients,with statistical significant differences(P＜0.05).Binary Logistic regres-sion analysis showed that serum HDAC3,CA125,and VEGF were related factors affecting stage Ⅲ/Ⅳ EMT pa-tients(OR＞1,P＜0.05).The ROC curve showed that the AUC of serum HDAC3,CA125,and VEGF for phaseⅢ/Ⅳ EMT evaluation were 0.898,0.701,and 0.795,respectively,and the AUC for combined detection evaluation was 0.956.Conclusions:The serum HDAC3 level is related to the severity of EMT patients,and gradually increa-ses with the increase of EMT staging.HDAC3 combined with CA125 and VEGF has a high preoperative evaluation value for stage Ⅲ/Ⅳ EMT patients.
