Mitochondrial abnormalities in polycystic ovary syndrome: a review

VernacularTitle:线粒体异常在多囊卵巢综合征中的研究进展
Author: Xina ZHEN ¹ ; Shan XIANG ; Fang LIAN
Author Information

1. 山东中医药大学第一临床医学院，济南　250011
Publication Type:Journal Article
Keywords: Polycystic ovary syndrome; Mitochondria; Oxidative phosphorylation; Oxidative stress
From: Chinese Journal of Reproduction and Contraception 2024;44(9):968-973
CountryChina
Language:Chinese
Abstract: Polycystic ovary syndrome (PCOS) is one of the most common endogenous diseases in women of childbearing age. Its main clinical features are hypertrophy, insulin resistance, ovulation dysfunction and so on, which may lead to the increase of long-term complications risk factors such as diabetes mellitus and cardiovascular disease. At present, the pathogenesis of PCOS includes but not limited to mitochondrial abnormalities, oxidative stress, vitamin D metabolism abnormalities, calcium homeostasis imbalance, but the specific mechanism has not been clarified. This article reviews the recent five years related research progress on mitochondrial abnormality and PCOS in order to provide theoretical basis for further exploration of its pathogenesis and explore more ideas for its treatment.