Diagnostic value of arterial spin labeling perfusion weighted imaging in the Alzheimer's disease
10.3969/j.issn.1002-1671.2025.09.004
- VernacularTitle:动脉自旋标记灌注加权成像在阿尔茨海默病中的诊断价值
- Author:
Pinpin LI
1
;
Wenhua GUAN
;
Pei LI
;
Yingying MIAO
;
Xueqiang YUE
;
Shengqi FU
Author Information
1. 新乡医学院第三附属医院放射科,河南 新乡 453003
- Publication Type:Journal Article
- Keywords:
arterial spin labeling perfusion weighted imaging;
brain structure;
Alzheimer's disease
- From:
Journal of Practical Radiology
2025;41(9):1441-1444,1476
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the application value of arterial spin labeling(ASL)perfusion weighted imaging in the early diagnosis of Alzheimer's disease(AD).Methods A total of 60 patients with different ages(control group)and 60 AD patients with different degrees(patient group)who underwent cerebral ASL perfusion weighted imaging examination were selected.At the work-station,the region of interest(ROI)of the hippocampus and limbic system brain structures were delineated and the cerebral blood flow(CBF)value of the ROI were measured.The CBF values of the brain structures of the control group at different ages and the corresponding ROI of the control group and the patient group were compared.Results There were statistically significant differences in the CBF values of the cingulate gyrus,parahippocampal gyrus,hippocampus,orbital part of frontal lobe,temporal pole of temporal lobe,insula lobe and amygdaloid body of the limbic system among the different ages in the control group(P＜0.05),and the CBF value of brain structures gradually decreased with the increase of age.There were statistically significant differences in CBF values of ROI between the control group and mild,moderate,severe patient group(P＜0.05),and the CBF value of brain structures gradually decreased with the severity of AD condition.Conclusion The CBF value of ASL perfusion weighted imaging can objectively reflect the blood flow changes and functional status of the hippocampus and limbic system brain structures in elderly people of different ages and AD patients of different degrees,and has important value in the early diagnosis of AD patients.
