Advances in the study of ferroptosis and testicular dysfunction
10.3760/cma.j.cn101441-20231101-00191
- VernacularTitle:铁死亡与睾丸功能障碍的研究进展
- Author:
Shiming WANG
1
;
Yingchun SU
1
;
Haixia JIN
1
;
Lin QI
1
Author Information
1. 郑州大学第一附属医院生殖医学中心，郑州 450052
- Publication Type:Journal Article
- Keywords:
Oxidative stress;
Testis;
Ferroptosis;
Male reproductive disorders
- From:
Chinese Journal of Reproduction and Contraception
2024;44(9):990-995
- CountryChina
- Language:Chinese
-
Abstract:
Iron homeostasis is essential for normal physiological metabolism in the human body, and disorders of iron metabolism are associated with the development of several diseases. Ferroptosis is mainly manifested by the accumulation of intracellular iron and lipid peroxides, with the antioxidant system as its main defense mechanism. Current studies have demonstrated that ferroptosis is closely related to oxidative stress and male infertility, and inhibiting the accumulation of iron and lipid peroxides may be a potential strategy for the treatment of ferroptosis-associated male reproductive diseases. Recently, the study of ferroptosis, a novel cell death mode, and male reproductive disorders has attracted extensive attention and continuous exploration by scholars. Therefore, this article combines the latest research progress, mainly elaborates on the effect of ferroptosis on testicular spermatogenesis, from the mechanism of iron death, the role of ferroptosis in testicular function, the relationship with male infertility, and the potential therapeutic strategies for related male reproductive diseases, to expand the ideas for the prevention and treatment of male reproductive diseases.
