Research progress on the role and mechanism of autophagy in endometrium
10.3760/cma.j.cn101441-20230322-00118
- VernacularTitle:自噬在子宫内膜中的作用及机制研究进展
- Author:
Hongwei LI
1
;
Xianghua DONG
;
Mingxia GAO
Author Information
1. 兰州大学第一临床医学院，兰州 730000
- Publication Type:Journal Article
- Keywords:
Autophagy;
Endometrial receptivity;
Endometrial disease
- From:
Chinese Journal of Reproduction and Contraception
2023;43(12):1296-1300
- CountryChina
- Language:Chinese
-
Abstract:
Autophagy is an important metabolic process that maintains homeostasis of cells, tissues and organisms. In endometrial cells, autophagy is involved in regulating endometrial growth and receptivity through a variety of pathways, including AMPK/TSC/mTOR signaling pathway, PI3K/AKT/mTOR signaling pathway, ATG4C, ULK4, RB1CC1/FIP200 and other related signaling pathways. These pathways are essential for maintaining intracellular environmental homeostasis and the health of the female reproductive system. At the same time, abnormal autophagy can lead to decreased endometrial receptivity and is associated with the occurrence and development of a variety of endometria-related diseases, and the level of autophagy presents dynamic changes in different periods of disease. In this paper, the role and mechanism of autophagy in endometrium were reviewed in order to provide relevant evidence for new drug development and treatment strategies. Deep understanding of the role and mechanism of autophagy in endometrium is expected to provide new ideas and directions for the treatment of endometrial diseases.
