Effects of short-term exposure to different levels of PM 2.5 on pregnancy outcomes in patients with early-follicular phase downregulation scheme
10.3760/cma.j.cn101441-20221110-00498
- VernacularTitle:短期不同水平PM 2.5暴露对早卵泡期降调节方案助孕患者妊娠结局的影响
- Author:
Beibei SHEN
1
;
Yupei TANG
;
Kui FU
;
Hongyi XU
;
Meng YANG
;
Yufang LIU
;
Zerui WANG
;
Haoyun LI
;
Zhifeng SUN
Author Information
1. 湖北医药学院生物医学工程学院，十堰 442000
- Publication Type:Journal Article
- Keywords:
Fertilization in vitro;
Embryo transfer;
PM 2.5;
Embryo quality;
Pituitary down-regulation;
Pregnancy outcome
- From:
Chinese Journal of Reproduction and Contraception
2023;43(11):1153-1157
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the effects of short-term (30 d) exposure to different levels of PM 2.5 on oocyte quality, embryo quality and pregnancy outcomes in patients with early-follicular phase downregulation scheme. Methods:From December 2018 to February 2019, and from July to September 2019, 348 patients with early-follicular phase downregulation scheme who underwent assisted reproduction and assisted pregnancy in the Reproductive Medicine Center, Renmin Hospital, Hubei University of Medicine were selected as the research objects in this retrospective cohort study. According to PM 2.5 new air quality standard, with 115 μg/m 3 as the cut-off value, the patients were divided into high exposure group ( n=94) and low exposure group ( n=254). During the period from the start of ovulation induction to the pregnancy test day, the activity areas of the patients are in the urban area of Shiyan City. The PM 2.5 of atmospheric fine particles during this period was calculated, including total amount and daily average amount. The effects of fine particulate matter PM 2.5 on ovum abnormality rate, embryo quality (number of available embryos, number of high-quality embryos, high-quality embryo rate, and blastocyst formation rate) and pregnancy outcome (pregnancy rate, abortion rate, live birth rate and proportion of low birth weight infants) were compared between the two groups. Results:Compared with the low exposure group, the number of available embryos (3.9±1.1 vs. 4.3±1.2, P=0.005), the number of high-quality embryos (2.9±1.5 vs. 3.4±1.7, P=0.001), high-quality embryo rate [35.5% (352/992) vs. 40.4% (792/1 959), P=0.009] and proportion of low birth weight infants [21.4% (12/56) vs. 5.13% (8/156), P<0.001] in the high exposure group were significantly decreased, and there was no significant difference in other data. Conclusion:Short-term exposure to high levels of PM 2.5 had significant negative effects on the number of available embryos, the number of high-quality embryos, the rate of high-quality embryos and proportion of low birth weight infants in the early-follicular phase down-regulation scheme.
