Analysis of clinical outcomes after embryo transfer again in IVF-ET/FET patients with previous spontaneous abortion in early pregnancy and fetal chromosomal abnormalities
10.3760/cma.j.cn101441-20221027-00476
- VernacularTitle:胚胎移植后早期自然流产伴绒毛染色体异常患者再次移植临床结局分析
- Author:
Wei ZHANG
1
;
Xianna LIU
;
Ning ZHANG
Author Information
1. 烟台毓璜顶医院生殖医学科，烟台 264000
- Publication Type:Journal Article
- Keywords:
Abortion, spontaneous;
Fertilization in vitro;
Embryo transfer;
Frozen-thawed embryo transfer;
Villus chromosome
- From:
Chinese Journal of Reproduction and Contraception
2023;43(11):1163-1167
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate clinical outcomes after embryo transfer again in in vitro fertilization and embryo transfer/frozen-thawed embryo transfer (IVF-ET/FET) patients with previous fetal chromosomal abnormalities. Methods:In this retrospective case-control study, data of patients who received IVF-ET/FET treatment at the Department of Reproductive Medicine, Yantai Yuhuangding Hospital between July 2015 and December 2019 and had embryo chromosomes tested after spontaneous abortion were analyzed. Among 299 patients, 172 cases were found to have fetal chromosomal abnormalities (abnormal group) and 127 cases were found to have normal results (normal group). We matched the above patients cycles with age, anti-Müllerian hormone and basal follicle-stimulating hormone using propensity score matching (PSM). Clinical data were analyzed again after PSM.Results:Before PSM, patients in abnormal group [34.0 (30.0,38.0) years] were significantly older than those in normal group [32.0 (30.0,36.0) years, P=0.015]. There were no statistically significant differences in clinical pregnancy rate, early miscarriage rate, approximate live birth rate and cumulative live birth rate (all P>0.05). After PSM matching, there were also no statistically significant differences in clinical pregnancy rate, early miscarriage rate, approximate live birth rate and cumulative live birth rate (all P>0.05). Conclusion:Patients with fetal chromosomal abnormalities can achieve similar clinical outcomes after embryo transfer again. Therefore IVF-ET or FET is recommended as early as possible.
