Risk and influencing factors of chronic obstructive pulmonary disease after asthma
10.12007/j.issn.0258-4646.2025.02.002
- VernacularTitle:哮喘后慢性阻塞性肺疾病发生风险及影响因素
- Author:
Guiya GUO
1
;
Wangchen SONG
1
;
Aimin WANG
1
;
Yujia KONG
1
;
Suzhen WANG
1
;
Fuyan SHI
1
Author Information
1. 山东第二医科大学公共卫生学院卫生统计学教研室,山东潍坊 261053
- Publication Type:Journal Article
- Keywords:
asthma;
chronic obstructive pulmonary disease;
United Kingdom Biobank;
multistate model;
influencing factor
- From:
Journal of China Medical University
2025;54(2):103-108,114
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the risk of chronic obstructive pulmonary disease(COPD)after asthma and explore factors influen-cing the onset and progression of asthma in patients with COPD.Methods A follow-up cohort was established based on the United Kingdom Biobank(UKB)database.The risk of asthma and COPD was predicted,and the influencing factors were analyzed using a mul-tistate model(MSM).Results Without considering the influence of covariates,the cumulative risk from COPD to mortality was the highest,followed by asthma to COPD,and asthma to mortality.Advanced age,male,diabetes mellitus(DM),high waist-to-hip ratio,hyper-tension,increased Townsend deprivation index,increased frequency of smoking,and family history were risk factors for developing COPD in the asthmatic population.Advanced age,male,DM,high waist-to-hip ratio,hypertension,increased Townsend deprivation index,and in creased frequency of smoking were risk factors for mortality in the asthmatic population.Advanced age,male,and DM and increased Townsend deprivation index were risk factors for mortality in the COPD population.Conclusion Advanced age,male,DM,high waist-to-hip ratio,hypertension,increased Townsend deprivation index,increased smoking frequency,and family history increased the risk of COPD in the asthmatic population.This MSM can be used to predict the influencing factors and degree of COPD after asthma,and reveal the change law of disease progression.
