Clinical Features of Patients With Pulmonary Arterial Hypertension Concomitant With Obstructive Sleep Apnea
10.3969/j.issn.1000-3614.2025.08.007
- VernacularTitle:动脉型肺动脉高压合并阻塞性睡眠呼吸暂停患者的临床特征研究
- Author:
Yiteng HUANG
1
;
Xiujun DAI
;
Dong HAN
;
Guanglin JIN
;
Qunying XI
Author Information
1. 中国医学科学院阜外医院深圳医院 肺血管综合病房,深圳 518057
- Publication Type:Journal Article
- Keywords:
pulmonary arterial hypertension;
sleep apnea,obstructive;
hypoxia
- From:
Chinese Circulation Journal
2025;40(8):776-781
- CountryChina
- Language:Chinese
-
Abstract:
Objectives:To investigate the clinical characteristics and prognosis of patients with pulmonary arterial hypertension(PAH)concomitant with obstructive sleep apnea(OSA).Methods:We analyzed the data of 208 patients diagnosed with PAH in the Pulmonary Vascular Diseases Ward of our hospital from September 2019 to August 2024,who underwent sleep breathing monitoring and echocardiography during hospitalization.Three clusters were identified:Cluster 1(n=121)had no OSA and mildly elevated N-terminal pro-B-type natriuretic peptide(NT-proBNP),Cluster 2(n=71)exhibited mild OSA and mildly elevated NT-proBNP,and Cluster 3(n=16)presented with moderate to severe OSA along with significantly elevated NT-proBNP.Results:The mean age of this patient cohort was(39±12)years,mean body mass index was(21.74±3.67)kg/m2,and 27.9%patients were male.Sixty-five patients(31.3%)had OSA.The echocardiographic indicators reflecting the structural function of the heart chambers and hemodynamic parameters in patients with PAH showed a significant correlation with nocturnal hypoxia.Compared to Cluster 1,patients in Cluster 2 and Cluster 3 had wider pulmonary arteries and inferior vena cava diameters,larger right ventricular diameters,higher pulmonary artery pressure,higher pulmonary vascular resistance,and lower cardiac index(all P<0.05).Cluster 3 patients had a significantly higher risk of death(log-rank P=0.022).Conclusions:Thirty-one percent of PAH patients in this study had concomitant OSA.PAH patients with significantly elevated NT-proBNP and comorbid moderate-to-severe OSA had a significantly higher risk of death compared to those with only mild or without OSA without significantly elevated NT-proBNP.Management strategies that address both PAH and OSA might be effective in improving the outcomes of these patients.
