Compatibility Study of Biapenem with Parenteral Nutrition Solution Mimicking Y-type Infusion Pathway
10.3870/j.issn.1004-0781.2025.09.018
- VernacularTitle:比阿培南与肠外营养液模拟Y型输液通路配伍的相容性
- Author:
Liguo WANG
1
;
Yantao YUE
1
;
Yuanpei LI
1
;
Lijie LOU
1
;
Liang ZHAO
1
Author Information
1. 许昌市中心医院药学部,许昌市智慧药学与药物临床应用重点实验室,许昌 461000
- Publication Type:Journal Article
- Keywords:
Biapenem;
Parenteral nutrition;
Physical and chemical compatibility;
Content determination;
Particle size;
Zeta potential
- From:
Herald of Medicine
2025;44(9):1490-1495
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the physical and chemical stability of biapenem and parenteral nutrient solutions when they are used together through a Y-type infusion pathway,and to evaluate the rationality and feasibility of clinical compatibility.Methods Based on the actual clinical infusion rates of biapenem solution and parenteral nutrition solution in ICU,under room temperature and light conditions,simulate a Y-shaped pathway to mix biapenem solution and four types of parenteral nutrition solutions in three volume ratios(1∶1,2∶1,3∶1),and collect the compatible solutions at 0,1,2,4,and 6 hours,observing the appearance,pH value,osmolality,insoluble particles,Zeta potential,particle size and the change of biapenem content of the compatible solution,to investigate the potential interaction between them.Results Within 6 hours,the appearance,pH value,osmotic pressure,insoluble particles,particle size,and Zeta potential did not significantly change.Compared with zero time,the content of the biapenem fluctuated between 93.68%and 100.86%,and there was no impurity peak interference in the chromatogram.Conclusion The physico-chemical properties of biapenem were stable within 6 hours under the condition of room temperature and no light exposure through Y-type infusion pathway and parenteral nutrient solutions.
