Clinical efficacy of stellate ganglion block combined with intranasal dexmedetomidine spray in patients with insomnia disorders
10.3969/j.issn.1006-5725.2025.03.013
- VernacularTitle:星状神经节阻滞联合右美托咪定经鼻喷雾治疗对失眠患者的疗效
- Author:
Ziqi HUANG
1
;
Xiaomin FAN
;
Fang LIU
;
Baojia LIN
;
Shunqing HU
;
Xiangyu LIU
;
Shuangrui WANG
;
Yongjia WANG
;
Xinjian ZHANG
Author Information
1. 广州中医药大学第三临床医学院(广东 广州 510405)
- Publication Type:Journal Article
- Keywords:
stellate ganglion block;
intranasal dexmedetomidine spray;
insomnia disorders
- From:
The Journal of Practical Medicine
2025;41(3):391-395
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical efficacy of stellate ganglion block(SGB)combined with intranasal dexmedetomidine for the treatment of insomnia.Methods A total of 64 patients aged 18 to 75 with insom-nia were randomly assigned to either the experimental group(DS group)or the control group(S group).The S group received SGB treatment for 14 consecutive days,whereas the DS group received an additional intranasal dexmedeto-midine spray at a dose of 100 μg,administered 30 minutes before bedtime on days 1 through 6,in conjunction with SGB.We measured and recorded the Pittsburgh Sleep Quality Index(PSQI),Self-Rating Depression Scale(SDS),Self-Rating Anxiety Scale(SAS)scores,and Psychomotor Vigilance Test(PVT)results for both groups at three time points:baseline(T1),the day after treatment(T2),and one month after treatment(T3).Results Intra-group Com-parison:In both the DS and S groups,PSQI scores and dimensionspecific scores at T2 and T3 were significantly lower compared to T1(P<0.05).SAS and SDS scores in both groups showed a significant reduction at T3 compared to T1 and T2(P<0.05),while PVT results exhibited no significant changes(P>0.05).Inter-group Comparison:The PSQI scores and dimensionspecific scores in the DS group at T2(8.44±2.99)and T3(8.22±2.60)were significantly lower than those in the S group at T2(10.88±2.56)and T3(10.88±2.84)(P<0.05).However,no significant differences were observed in SDS and SAS scores between the DS and S groups at T2 and T3(P>0.05).Conclusion Compared to standalone SGB,the combination of SGB with intranasal dexmedetomidine significantly enhances sleep quality in patients with insomnia,while not impacting their levels of anxiety,depression,or alertness.
