Effect of Kaiqiao Xingshen acupuncture combined with Buyang Huanwu decoction on IL-2,MMP-9,BDNF,and cerebral blood flow in patients with cerebral hemorrhage during recovery period(Qi defi-ciency and blood stasis syndrome)
10.3969/j.issn.1006-5725.2025.03.019
- VernacularTitle:开窍醒神针法联合加味补阳还五汤对脑出血恢复期患者(气虚血瘀证)IL-2、MMP-9、BDNF及脑血流量的影响
- Author:
Tianzhong PENG
1
;
Xuedi HUANG
;
Xingzhen LIN
;
Juan YUAN
;
Feng ZHOU
;
Langhui LIU
;
Qi'nan ZHAN
;
Manhua ZHU
Author Information
1. 南昌市洪都中医院康复医学科(江西 南昌 330008)
- Publication Type:Journal Article
- Keywords:
Kaiqiao Xingshen acupuncture;
Buyang Huanwu decoction;
inflammatory factors;
recovery period of cerebral hemorrhage;
Qi deficiency and blood stasis;
MMP-9;
BDNF;
cerebral blood flow
- From:
The Journal of Practical Medicine
2025;41(3):428-433
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the application value of Kaiqiao Xingshen acupuncture combined with Buyang Huanwu decoction in the treatment of patients with cerebral hemorrhage in the recovery period(Qi defi-ciency and blood stasis syndrome),and to observe its impact on inflammatory indicators and neurokines.Method A total of 166 patients with cerebral hemorrhage in the recovery period(Qi deficiency and blood stasis syndrome)treated in Hongdu Traditional Chinese Medicine Hospital from September 2021 to October 2023,were randomly divided into control group(83 cases treated with conventional western medicine),and observation group(83 cases treated with a combination of Kaiqiao Xingshen acupuncture and Buyang Huanwu decoction).The therapeutic effect in the two groups was compared after 8 weeks of treatment.Results After treatment,the serum levels of matrix metalloproteinase-9(MMP-9),endothelin-1(ET-1),interleukin-2(IL-2),homocysteine(Hcy),and Bcl-2-associated X protein(bax)decreased in both groups,while brain-derived neurotrophic factor(BDNF)increased,and the improvement was more significant in the observation group,showing statistical significance(P<0.05);the average cerebral vascular flow and flow velocity in the observation group increased,while peripheral vascular resistance decreased,and the improvement in the observation group was more significant(P<0.05);the total symptom score of traditional Chinese medicine in the observation group decreased,while the Fuel Meyer functional score(FMA score)increased,and the improvement in the observation group was more significant(P<0.05);The total effective rate of the observation group was 93.98%(78/83),which was higher than that of the control group(80.72%,67/83)(P<0.05).Conclusion For patients with cerebral hemorrhage in the recovery period(Qi deficiency and blood stasis syndrome),Kaiqiao Xingshen acupuncture and Buyang Huanwu decoction help alleviate inflammatory reactions,promote the recovery of the blood-brain barrier,improve cerebral blood flow,promote neurological function recovery,and enhance clinical efficacy.
