Research progress on the effect of gastrointestinal microbiota on intrahepatic cholestasis of pregnancy
10.3760/cma.j.cn101441-20220911-00395
- VernacularTitle:肠道菌群在妊娠期肝内胆汁淤积症发病中作用的研究进展
- Author:
Jiajing CHAO
1
;
Xinghua SHI
;
Bingxiang CHEN
;
Mingqing LI
Author Information
1. 启东市妇幼保健院（复旦大学附属儿科医院启东分院）妇产科，启东 226200
- Publication Type:Journal Article
- Keywords:
Intrahepatic pregnancy of cholestasis;
Pregnancy;
Gastrointestinal microbiota;
Bile acid
- From:
Chinese Journal of Reproduction and Contraception
2024;44(1):26-31
- CountryChina
- Language:Chinese
-
Abstract:
Intrahepatic cholestasis of pregnancy (ICP), as an idiopathic disease, often occurs in the second and third trimester of pregnancy. It is characterized by maternal pruritus, abnormal liver function and raised serum bile acids which are resolved rapidly and spontaneously after delivery. It has been reported that abnormal intestinal microbiota and endogenous bile acids play important roles in the progression of cholestatic liver diseases. Dramatic changes in metabolic hormone levels and energy metabolism during pregnancy disrupt the microbiota composition and bile acid pool as well. Altered intestinal permeability, overaccumulation of bile acids, aberrant expression of bile acid transporters and nuclear receptors are all involved in the pathogenesis of cholestasis. This paper reviews the changes of intestinal flora and the mechanism of gastrointestinal microbiota in intrahepatic cholestasis of pregnancy, explore the potential treatments for ICP.
