Effect of Wenyang Huazhuo recipe on pregnancy outcomes in patients with unexplained recurrent spontaneous abortion
10.3760/cma.j.cn101441-20230714-00011
- VernacularTitle:温阳化浊方对不明原因复发性流产患者妊娠结局的影响
- Author:
Yunhuan QIU
1
;
Saihua MA
;
Tiantian MA
;
Yiran CHEN
;
Baojuan WANG
;
Rong DONG
;
Xiaozhou LI
;
Duan JU
;
Tian XIA
Author Information
1. 天津中医药大学第一附属医院生殖中心 国家中医针灸临床医学研究中心，天津 300193
- Publication Type:Journal Article
- Keywords:
Pregnancy outcome;
Traditional Chinese Medicine;
Wenyang Huazhuo recipe;
Unexplained recurrent spontaneous abortion;
Live birth rate
- From:
Chinese Journal of Reproduction and Contraception
2024;44(4):347-352
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the effect of Wenyang Huazhuo recipe (WYHZ) on pregnancy outcomes in patients with unexplained recurrent spontaneous abortion (URSA).Methods:A retrospective cohort study was used and 240 cases of pregnancy URSA patients with spleen kidney yang deficiency syndrome at the Reproductive Center, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine and Department of Gynaecology and Obstetrics, General Hospital of Tianjin Medial University from November 2018 to March 2022 were recruited. The patients were assigned to WYHZ group (120 cases) and control group (120 cases) based on whether accepting oral WYHZ from 3 months before pregnancy to 8-12 weeks after pregnancy regularly. Pregnancy outcomes, perinatal period outcomes and obstetric complications were compared between the two groups. Multivariate logistic regression were used to analyze the effect of WYHZ on pregnancy outcome.Results:The live birth rate and the clinical pregnancy rate in WYHZ group [86.67% (104/120), 90.00% (108/120)] were higher than those in control group [71.67% (86/120), P=0.004; 75.00% (90/120), P=0.002]. The early abortion rate in WYHZ group [10.08% (12/119)] was lower than that in control group [25.86% (30/116), P=0.002], the differences were statistically significant. There were no significant differences in perinatal outcome and incidence rate of obstetric complications between the two groups (all P>0.05). Multivariate logistic regression analysis showed that the application of WYHZ significantly improved the live birth rate ( OR=8.818, 95% CI: 3.556-21.871, P<0.001) and sustained pregnancy rate ( OR=11.261, 95% CI: 4.262-29.751, P<0.001) in URSA patients. Conclusion:WYHZ using before and during pregnancy can significantly improve the live birth rate and the clinical pregnancy rate of URSA patients with syndrome of yang deficiency of spleen and kidney, and improve their pregnancy outcomes.
