Analysis on birth defects in offspring after assisted reproductive technology in Beijing from 2010 to 2019
10.3760/cma.j.cn101441-20221222-00582
- VernacularTitle:2010—2019年北京市辅助生殖技术助孕后子代出生缺陷发生情况分析
- Author:
Jie BAO
1
;
Lixue CHEN
1
;
Hongping WU
1
;
Ping LIU
1
;
Jie QIAO
1
;
Rong LI
1
;
Yuanyuan WANG
1
;
Hongbin CHI
1
Author Information
1. 北京大学第三医院妇产科生殖医学中心 北京市人类辅助生殖技术质量控制和改进中心 国家妇产疾病临床医学研究中心 辅助生殖教育部重点实验室 北京市生殖内分泌与辅助生殖技术重点实验室，北京100191
- Publication Type:Journal Article
- Keywords:
Reproductive techniques, assisted;
Birth defects;
Incidence rate;
Trend
- From:
Chinese Journal of Reproduction and Contraception
2023;43(6):583-587
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the incidence rate and development trend of birth defects in offspring after assisted reproductive technology (ART) in Beijing from 2010 to 2019.Methods:The institutions that carry out ART in Beijing were retrospectively investigated. The follow-up outcomes and the incidence of birth defects in a total of 389 978 ART treatment cycles were collected from 8 ART institutions between January 1, 2010 to December 31, 2019.Results:There were 1 367 ART pregnancies with birth defects, and the overall incidence rate was 120.87/10 000. The most common anomalies were malformations of circulatory system. The annual increase in birth defects was slightly higher during the pregnancy loss cycles (108.36%) than during the delivery cycles (103.77%). There was no significant difference in the prevalence of birth defects between artificial insemination (123.15?) and in vitro fertilization technology (105.23? , P=0.097). Conclusion:In recent 10 years, the incidence rate of birth defects in offspring conceived by ART at 8 reproductive centers in Beijing showed an increasing trend. The implementation of the tertiary prevention strategy of birth defects should be further strengthened to reduce the number of newborns with birth defects.
