Recent development of organoids and organ-on-a-chip in creation of an in vitro model of the placenta
10.3760/cma.j.cn101441-20220901-00376
- VernacularTitle:类器官及器官芯片技术在体外胎盘模型构建中的研究进展
- Author:
Xiaolu ZHANG
1
;
Jinzhi LI
;
Li WANG
;
Songping LIU
Author Information
1. 复旦大学附属金山医院妇产科，上海 201508
- Publication Type:Journal Article
- Keywords:
Organoid;
Organ-on-a-chip;
Placental barrier;
In vitro model
- From:
Chinese Journal of Reproduction and Contraception
2023;43(11):1191-1197
- CountryChina
- Language:Chinese
-
Abstract:
The placenta is the site of material exchange and barrier between mother and the offspring, plays a crucial role in the growth of fetus. Dysfunction of placenta is responsible for varies of adverse pregnancy outcome. Current in vitro experimental models of the placenta all have their limitations and are insufficient for research. Recently, organoid and organ-on-a-chip technology develop rapidly, and provide a potentially powerful approach to drug discovery and basic medical research. Organoids derived from human placenta closely resemble origin trophoblast in cell phenotype, genetic expression and so on. Placenta organ-on-a-chip mimics the placenta barrier and has been used in research of drug transport across the placenta. Establishment of placenta organoid-on-a-chip, or multi-organ chip contains placenta and endometrium cells can be a potential direction of research in the future.
