Effects of growth hormone in patients with repeated implantation failures undergoing fresh embryo transfer: a retrospective cohort study
10.3760/cma.j.cn101441-20220914-00396
- VernacularTitle:生长激素在反复种植失败患者鲜胚移植中的作用：一项回顾性队列研究
- Author:
Fenting LIU
1
;
Ping ZHOU
1
;
Shuo YANG
1
;
Rong LI
1
Author Information
1. 北京市生殖内分泌与辅助生殖技术重点实验室 辅助生殖教育部重点实验室(北京大学) 国家妇产科临床医学研究中心 北京大学第三医院妇产科生殖医学中心，北京 100191
- Publication Type:Journal Article
- Keywords:
Growth hormone;
Repeated implantation failures;
Live birth rate
- From:
Chinese Journal of Reproduction and Contraception
2023;43(11):1126-1131
- CountryChina
- Language:Chinese
-
Abstract:
Objectives:To investigate whether adjuvant treatment with growth hormone (GH) can improve the pregnancy outcomes of patients with fresh embryo transfer after repeated implantation failures (RIF).Methods:This retrospective cohort study was performed in patients who underwent in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) fresh transfer cycle and were expected RIF from January 2016 to December 2020 in Reproductive Medicine Center, Department of Obstetrics and Gynecology, Peking University Third Hospital. Using SPSS26.0, a 1∶1 propensity score matching was conducted based on age, body mass index (BMI), infertility factors, and antral follicle count with a caliper value of 0.015. The data obtained were then divided into GH treatment group ( n=552) and non-GH treatment group ( n=552). The controlled ovarian stimulation outcomes, implantation rate, clinical pregnancy rate, and live birth rate were compared between the two groups. Results:The implantation rate, the clinical pregnancy rate and the live birth rate of RIF patients in GH treatment group and non-GH treatment group were not significantly different (all P>0.05). Furthermore, analysis of various groups based on ovulation induction protocols similarly indicated no statistically significant differences in live birth rate, implantation rate, and clinical pregnancy rate between the two groups (all P>0.05). Logistic regression also indicated that GH adjuvant therapy has no effect on the live birth rate in RIF patients ( OR=1.035, 95% CI: 0.720-1.487, P=0.854). Conclusion:Adjuvant GH treatment may not improve the live birth rate of fresh embryo transfer in RIF patients.
