Research progress on the repair mechanisms of DNA damage in human embryonic stem cells

VernacularTitle:人类胚胎干细胞DNA损伤修复机制的研究进展
Author: Peng ZENG ¹ ; Xiaorong WU ¹ ; Minyao LI ¹ ; Manqin ZHANG ¹ ; Mei TIAN ¹ ; Yonggang LI ¹
Author Information

1. 国家卫生健康委西部优生与出生缺陷防控重点实验室　云南省第一人民医院生殖医学科　昆明理工大学附属医院，昆明　650034
Publication Type:Journal Article
Keywords: Genomic instability; Human embryonic stem cells; DNA repair mechanisms; Stem cell therapy
From: Chinese Journal of Reproduction and Contraception 2024;44(3):331-336
CountryChina
Language:Chinese
Abstract: Embryonic stem cells have remarkable proliferative and differentiation developmental capabilities and thus have great potential for cell therapy, disease modeling, and drug development. However, such totipotency has resulted in genomic instability, especially in the case of DNA damage. Human embryonic stem cells possess particular repair mechanisms to avoid the accumulation of such damage within the cell or its transmission to the offspring, thus ensuring the accuracy and safety of self-replication and differentiation development. This paper summarized the repair mechanisms of DNA damage in human embryonic stem cells and intends to provide a basis for further exploration of new ideas of stem cell therapy in conjunction with their repair mechanisms.