Molecular Mechanism of Premature Ovarian Insufficiency Mediated by Oxidative Stress-induced Granulosa Cell Damage
10.13865/j.cnki.cjbmb.2025.04.1025
- VernacularTitle:氧化应激诱导颗粒细胞损伤致早发性卵巢功能不全的分子机制
- Author:
You TAN
1
;
Shi-Yan SUI
1
;
Bi-Rong ZHANG
1
Author Information
1. 大理大学公共卫生学院,云南大理 671000
- Publication Type:Journal Article
- Keywords:
granulosa cells(GCs);
oxidative stress(OS);
premature ovarian insufficiency(POI);
apoptosis;
autophagy
- From:
Chinese Journal of Biochemistry and Molecular Biology
2025;41(8):1137-1148
- CountryChina
- Language:Chinese
-
Abstract:
Premature ovarian insufficiency(POI),also known as premature ovarian failure(POF),is one of the major causes of female infertility.Its incidence has been increasing year by year,seriously af-fecting women's reproductive health and becoming an increasingly serious public health problem world-wide.The pathogenesis of POI is complex and may be related to genetic,immune and environmental fac-tors,but in recent years,oxidative stress(OS)has received widespread attention as a key factor that can affect the function of ovarian granulosa cells(GCs),which can lead to the occurrence of POI.Reactive oxygen species(ROS)regulate the proliferation,survival and apoptosis of GCs through multiple signaling pathways,such as PI3K-Akt,MAPK,TGF-β/Smad,Notch,etc.AMPK and mitochondrial autophagy play important roles in attenuating the ROS damage and protecting the ovarian function.Excessive ROS disrupts the autophagy and lysosomal functions,leading to the accumulation of intracellular waste prod-ucts,thus affecting the physiological function and endocrine stability of GCs.In addition,OS can in-crease the risk of POI by affecting hormone synthesis and disrupting the function of GCs,leading to an imbalance in estrogen and progesterone levels.Herein we review the mechanism of OS in POI,explore how OS affects ovarian decline through the regulation of signaling pathways and cellular functions,and provide a theoretical basis for the clinical treatment of POI,which in turn provides new research ideas for its early diagnosis and prevention.
