Bone Marrow Microenvironment and Targeted Therapies for Multiple Myeloma
10.13865/j.cnki.cjbmb.2025.06.1492
- VernacularTitle:多发性骨髓瘤骨髓微环境及其靶向治疗策略
- Author:
Hao CHENG
1
;
Zhi-Qiang LIU
Author Information
1. 山东省肿瘤精准防治重点实验室,山东省肿瘤医院,山东第一医科大学,济南 250022;天津医科大学基础医学院生理学与病理生理学系,天津 300070
- Publication Type:Journal Article
- Keywords:
multiple myeloma(MM);
bone marrow microenvironment(BMME);
cancer drug resistance
- From:
Chinese Journal of Biochemistry and Molecular Biology
2025;41(8):1085-1095
- CountryChina
- Language:Chinese
-
Abstract:
Multiple myeloma(MM)is a hematologic malignancy characterized by clonal proliferation of plasma cells within the bone marrow,with pathological features including abnormal secretion of mono-clonal immunoglobulins,osteolytic bone disease,and multi-organ dysfunction.Despite significant ad-vancements in therapeutic approaches that have markedly extended patient survival,primary drug resist-ance and relapse remain major obstacles to clinical cure.The pathogenesis and progression of MM are in-tricately regulated by the bone marrow microenvironment(BMME),a dynamic network composed of di-verse cellular and non-cellular components.The BMME not only supports the survival and proliferation of MM cells but also plays a pivotal role in disease progression by modulating bone metabolic homeostasis,mediating immune escape,and promoting drug resistance.In recent years,groundbreaking therapeutic strategies targeting the BMME have emerged,including immunomodulatory drugs,bispecific antibodies,CAR T-cell therapies,and microenvironment-modulating agents.These approaches have significantly im-proved objective response rates and survival outcomes in relapsed/refractory MM by disrupting cytokine signaling,reprogramming the immunosuppressive microenvironment,or inhibiting tumor-stromal interac-tions.However,challenges such as drug resistance,treatment-related toxicity,and tumor heterogeneity persist in clinical practice.This review systematically delineates the roles of BMME components in MM pathogenesis,analyzes the molecular mechanisms underlying MM cell-BMME interactions,and explores innovative strategies to enhance therapeutic efficacy and prognosis through targeted modulation of the BMME.These insights provide a foundation for developing novel therapeutic paradigms aimed at overco-ming current limitations in MM treatment.
