Perinatal outcomes of singleton live birth resulting from human assisted reproductive technology: a retrospective propensity score matching cohort study
10.3760/cma.j.cn101441-20221130-00531
- VernacularTitle:人类辅助生殖技术单胎活产的围产期结局：一项回顾性倾向性评分匹配队列研究
- Author:
Wei ZHENG
1
;
Bingnan REN
1
;
Chen YANG
1
;
Shiyu RAN
1
;
Huan WU
1
;
Rui WANG
1
;
Shanshan DOU
1
;
Ran SHEN
1
;
Jingyi HAN
1
;
Peixin LI
1
;
Yichun GUAN
1
Author Information
1. 郑州大学第三附属医院生殖医学中心，郑州 450052
- Publication Type:Journal Article
- Keywords:
Reproductive techniques, assisted;
Spontaneously conceived;
Singleton live births;
Perinatal outcomes
- From:
Chinese Journal of Reproduction and Contraception
2023;43(6):559-565
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare perinatal outcomes of singleton live births between human assisted reproductive technology (ART) and spontaneously conceived (SC).Methods:This study was a retrospective cohort study, collecting data on patients who delivered and obtained singleton live birth in the Obstetrics Department of the Third Affiliated Hospital of Zhengzhou University between 2008 and 2019. A total of 1 727 ART patients were included in this study, and 5 181 SC patients who delivered during the same day were matched at a ratio of 1∶3. After matching according to delivery time, the baseline data of the two groups were matched using 1∶1 propensity score matching (PSM), and finally 1 439 patients were included in the ART and SC groups, respectively. The primary outcome measure was the healthy baby rate, and the secondary outcome measures were perinatal outcomes such as the incidences of hypertensive disorders of pregnancy, gestational diabetes and preterm delivery rate.Results:After PSM, healthy baby rate was lower in the ART group compared with the SC group [77.28% (1 112/1 439) vs. 70.67% (1 017/1 439), P<0.001]. Pregnancy complications, including the incidence of gestational diabetes, intrahepatic cholestasis syndrome during pregnancy, abnormal thyroid function during pregnancy, oligohydramnios, placenta previa, cesarean delivery, and placental efficiency, were statistically different between the two groups (all P<0.05). The neonatal outcomes, including gestational age, preterm delivery rate, very preterm delivery rate, incidence of small for gestation age and neonatal intensive care unit admission rate were statistically different between the two groups (all P<0.05). The results of multivariate logistic regression analysis showed that ART and pregnancy complications were risk factors for healthy baby ( OR=0.81, 95% CI:0.67-0.97, P=0.020), however, placental efficiency was a protective factor for healthy baby ( OR=1.73, 95% CI:1.59-1.88, P<0.001). Conclusion:Perinatal outcomes were safer in the SC group than in the ART group.
